Care should be taken not to confound aphorisms with axioms. Aphorisms come into being as the result of experience. This is also often the case with axioms (see axiomatization; Euclidean geometry), but due to their apparent certainty, axioms are then regarded as assertions not requiring proof, and used as the starting point for further deductive reasoning. Aphorisms have been especially used in dealing with subjects such as art, agriculture, medicine, jurisprudence, psychology, and politics, to which little methodical or scientific treatment was applied at the time.
Aphoristic collections, sometimes known as wisdom literature, have a prominent place in the canons of several ancient societies: E.g. the Biblical Book of Proverbs, Islamic Hadith, Hesiod's Works and Days, or Epictetus' Handbook. Aphoristic collections also make up an important part of the work of some modern authors, such as Georg Christoph Lichtenberg, Friedrich Nietzsche, Franz Kafka, Karl Kraus, La Rouchefoucauld, Thomas Szasz, Stanislaw Jerzy Lec, Mikhail Turovsky, Celia Green, Robert A. Heinlein, Gay Walley, E.M.Cioran, and Leonard Wisdon. A 1559 oil-on-oak-panel painting, Netherlandish Proverbs (also called The Blue Cloak or The Topsy Turvy World) by Pieter Brueghel the Elder, artfully depicts a land populated with literal renditions of Flemish aphorisms (proverbs) of the day.